– Our study suggests it is caused by inherited dopamine receptor deficits – likely in the D2, maybe D1 as well.
– Family history is one of the best diagnostic tools
We have not seen pre-frontal cortex damage as cause before but this research seems good. We are not scientists but associate the cortical regions with the “brakes” and brain-stem and mid-brain as the accelerator.
We also suggest the dopamine receptor deficits drive hyper-seeking behavior in addictions which is different from a reward-driven model. Subtle but likely important difference.
Welcome to my blog about addiction. When I use the word addiction, I am referring to any obsessive-compulsive behaviors involving chemical subtances, food, sex, gambling, shopping, exercise, work, the computer/internet, stealing, video games, and other pleasurable behaviors. Although a large portion of the discussion is dedicated to substance addiction, a majority of the information can also be applied to other addictions/compulsions. But, the point is that anything pleasurable can become addictive, and all pleasure involves the neurochemical DOPAMINE. Understanding how this chemical works is key to recovery.